Nucleofill is a bio stimulant gel based on natural polynucleotides and high viscosity for skin rejuvenation and protection. As an anti-ageing treatment. Nucleofill is designed to improve skin elasticity and tightness as well as aid in the prevention of wrinkles. Nucleofill is the new line of natural polynucleotide-based bio stimulating gels, with a high viscosity, for protecting and rejuvenating the skin. It’s recommended to have 2 treatments with 2-4 weeks in between each session, in severe cases you can have up to 4 treatments with 2-4 weeks intervals. The product contains high molecular weight polynucleotide chains whose biochemical peculiarities make it highly viscoelastic and capable of binding and orient in space a considerable amount of water molecules, which are primarily retained in the hydrophilic groups level of phosphorylated sugars of the individual nucleotides. The strong moisturising ability is mainly due to the water retention capabilities of the hydrophilic groups of the phosphorylated sugars of the single nucleotides. An “electrostatic sponge” able to guarantee cellular well-being by conferring deep hydration to tissues. Free radical scavenger effect – The polymeric macromolecules are able to also play an immediate “scavenger” action against free radicals. This effect of this polynucleotide gel is possible thanks to the chemical structure capable of blocking free radicals in the nitrogenous ring. Moreover, the progressive degradation of polynucleotide molecules by enzymes present in the extracellular environment, free metabolites which, in turn, accentuate the protection activity against free radicals. The biostimulating effect is given both by the presence of nucleoside structures capable of activating cell membrane receptors, and by metabolites that are produced by the enzymatic attack during the degradation process. A slow and continuous effect. By promoting the metabolic activity of the fibroblastic cells, polynucleotides collaborate to reintegrate into the dermis various fundamental autologous components (glucoseaminoglycans, proteins, glycoproteins, fibrils, etc.) tending to maintain their physiological functionality. Their repeated administration over time, determines: – a protracted isosmotic hydration of the dermal matrix – an anti-radical action Both of these effects combine to recreate in the dermal matrix the most favourable physiological conditions for the regeneration and metabolic activity of fibroblasts, with long-lasting biorevitalising effects. Polynucleotides activate two types of membrane receptors in fibroblasts, or rather Receptor CD39 and Receptor CD40. The activation of these receptors lead to two effects: stimulation of type I collagen production, saturation of fibroblasts in myofibroblasts Contains: 25mg/ml of polynucleotides 2 disposable sterile needles 30G The synergy of 4 types of stimulation: – Skin regeneration – Cleansing effect on the cells by increasing circulation and removing  free radicals – Deep moisturising effect – Firming and contouring Indications: – Loose skin with poor circulation – Dehydrated skin – Skin submitted to oxidative stress – Stretch marks – Scars – For those who want firming and contouring, more definition – Bio-stimulation and increase in collagen type 1.